Detoxifies Mycotoxins

Reduction in the mold quantity, inhibition of mycotoxin production and binding by clay and other material though eliminate majority of mycotoxin yet, some quantity of toxins invariably reaches in the system. These mycotoxins then get metabolites in the liver majorly and eliminated from the body.

Thus the process of detoxification (to get rid of harmful toxins which get metabolized with various ways and waiting to be thrown out of the body) occurs to eliminate the toxin production is unobstructed, mycotoxins received by animal, reaches the liver and detoxified. Under the influence of various enzymes, detoxification process occurs.

After the resorption in GIT, the principal target organ for mycotoxin is the liver in all species. And the detofixification of mycotoxins occurs in the liver through complex enzymatic process.

Liver detoxification depends on the enzyme activation such as cytochrome P450 system and Phase-I. Phase-I is characterized by functionalization reactions like oxidative, reductive or hydrolytic reactions. This phase can either bioactive or detoxify mycotoxin. This metabolic mechanism always follows a specific route and is divided into three phases. The metabolites of this phase enter Phase-II of the detoxification, characterized by conjugation reactions through transferases. This step is the actual detoxification. These conjugated metabolites enter Phase-III, characterized by transporters that are responsible for the excretion of the conjugated metabolites.

Researches show that;

•      Reduces the level of serum bilirubin and lipid in liver,

•      Accelerated the mycotoxin metabolism in liver,

•      Increased liver enzyme activity

•      Prevent liver damage

Phora’s phytogenic blend showed inhibitory effects and a structure activity study established that beta-diketone groups linked with two benzyl moieties were essential for inhibition of aflatoxicol formation. To make a comparison 37 naturally occurring compounds tested did not inhibit formation of aflatoxicol. These results demonstrate that dietary constituents in certain fruits, vegetables and spices may have significant inhibitory effects on metabolic transformation of aflatoxins to their hepatotoxic or carcinogenic derivatives or alternatively may promote their transformation in to nontoxic products.